Table 1.
Demographics and disease characteristics of the four cohorts at baseline
| Baseline parameter |
rHSA/IFNα2a
600 μg
(n = 8) |
rHSA/IFNα2a
750 μg
(n = 8) |
rHSA/IFNα2a
900 μg
(n = 8) |
Peg‐IFNα2a
180 μg
(n = 8) |
P |
|---|---|---|---|---|---|
| Gender (male/female) | 6/2 | 5/3 | 6/2 | 4/4 | >0.05 |
| Ethnic (Han/other) | 7/1 | 7/1 | 8/0 | 8/0 | >0.05 |
| Age, mean (SD) years | 39.88 ± 9.43 | 30.88 ± 7.75 | 36.50 ± 10.98 | 25.00 ± 4.14 | >0.05 |
| Smoker (yes/no) | 1/7 | 3/5 | 1/7 | 3/5 | >0.05 |
| Drinker (yes/no) | 2/6 | 0/8 | 0/8 | 1/7 | >0.05 |
| BMI, mean (SD), kg m −2 | 22.83 ± 2.41 | 22.86 ± 2.70 | 23.31 ± 2.68 | 21.55 ± 2.72 | >0.05 |
| HBV DNA, mean (SD) log 10 IU/ml | 7.93 ± 0.63 | 7.64 ± 0.79 | 7.28 ± 1.14 | 7.33 ± 0.92 | >0.05 |
| HBsAg, IU ml −1 | >250 | >250 | >250 | >250 | – |
| HBeAg, IU ml −1 | 755.67 ± 505.23 | 509.81 ± 477.99 | 464.41 ± 564.22 | 805.19 ± 524.76 | >0.05 |
| ALT, mean (SD) U l −1 | 189.13 ± 71.27 | 199.50 ± 99.80 | 141.63 ± 51.65 | 139.63 ± 63.86 | >0.05 |
| HBeAg negative, n (%) | 1 (12.5) | 2 (25) | 0 (0) | >0.05 |