Table 8.

Linear regression analysis between exposure of rHSA/IFNα2a and its dosage

PK parameter	Dosing	Regression coefficient	Lower 90% CI	Upper 90% CI
C max	First dose	0.35	−0.67	1.37
C max	Last dose	2.33	0.27	4.38
AUC 0–t	First dose	0.86	0.13	1.59
AUC 0–t	Last dose	2.41	−0.23	5.06
AUC 0–∞	First dose	0.85	0.04	1.66
AUC 0–∞	Last dose	2.31	−0.28	4.91

Last dose: IFNα2a serum concentration achieved a steady state after multiple doses, and pharmacokinetic parameters were C _ssmax, AUC_ss0–t and AUC_ss0–∞, respectively. PK, pharmacokinetic.