Table 9.

Comparison of kinetics parameters of neopterin between the first and last dosing in each group

Group		T max	C max	AUC 0–t
		h	Nmol l −1 ml −1	Nmol l −1 ml −1 *h
rHSA/IFNα2a 600 μg	First dose	78.00 ± 45.36	29.24 ± 7.37	10 607.02 ± 2893.85
	Last dose	68.33 ± 54.59	19.71 ± 6.71	8759.53 ± 3026.83
	P	0.79	0.05	0.07
rHSA/IFNα2a750 μg	First dose	66.00 ± 24.00	41.32 ± 7.59	14 677.07 ± 2778.31
	Last dose	94.29 ± 38.84	26.98 ± 5.13	12 232.28 ± 2969.15
	P	0.08	0.02	0.13
rHSA/IFNα2a 900 μg	First dose	55.50 ± 27.91	35.00 ± 11.45	12 464.27 ± 3781.08
	Last dose	89.14 ± 45.88	20.93 ± 7.72	8268.78 ± 2181.01
	P	0.06	0.02	0.02
PEG‐IFNα2a 180 μg	First dose	51.00 ± 22.90	40.70 ± 14.29	8939.34 ± 2368.70
	Last dose	87.00 ± 27.77	28.36 ± 3.96	10 348.77 ± 2107.19
	P	0.03	0.04	0.07

Last dose: IFNα2a serum concentration achieved a steady state after multiple doses, and pharmacokinetic parameters were C _ssmax, AUC_ss0–t, AUC_ss0–∞, t _{ss 1/2,} T _ssmax, CLz/F_ss, MRT_ss0–∞, and Vz/F_ss, respectively.