Table 3.
Pharmacokinetic parameters for administered compounds
| Fentanyl | (S)‐ketamine | Norketamine | Phenytoin | Ibuprofen | Imipramine | Desipramine | Pregabalin | |
|---|---|---|---|---|---|---|---|---|
| C max (ng ml –1 ) | 1.23 ± 0.66 | 52.4 ± 15.7 | 23.2 ± 5.7 | 8280 ± 1740 | 53 300 ± 9360 | 77.2 ± 21.1 | 25.4 ± 14.6 | 9650 ± 1880 |
| T max (h) | 0.50 (0.50–1.22) | 0.50 (0.50–2.33) | 1.10 (1.05–3.05) | 0.55 (0.50–2.13) | 2.02 (1.08–3.00) | 3.12 (1.08–6.00) | 6.00 (2.07–10.00) | 1.56 (1.08–5.00) |
| T 1/2 (h) | 2.52 ± 1.08 | 3.12 ± 1.30 | 4.89 ± 1.14 | 12.50 ± 2.86 | 1.80 ± 0.29 | 6.54 ± 1.96 | 56.2 ± 8.7 | 5.30 ± 0.58 |
| AUC 0–last (ng hr ml –1 ) | 2.21 ± 0.72 | 102 ± 18.6 | 129 ± 35.7 | 54 500 ± 7980 | 174 000 ± 30 200 | 441 ± 128 | 163 ± 99.2 | 49 700 ± 7340 |
| AUC 0–inf (ng hr ml –1 ) | 3.10 ± 0.84 | 111 ± 22.2 | 180 ± 54.6 | 135 000 ± 34 800 | 182 000 ± 35 600 | 782 ± 193 | 517 ± 100 | 71 200 ± 9860 |
| Clearance (l hr –1 ) | 1.05 ± 0.32 | 93.6 ± 20.1 | 60.2 ± 17.7 | 2.36 ± 0.54 | NC | NC | NC | NC |
| V d (l) | 3.56 ± 1.29 | 410 ± 153 | 411 ± 106 | 40.60 ± 4.97 | NC | NC | NC | NC |
Data are means ± standard deviation and median (range) for Tmax.
AUC0–inf, estimated area under the plasma concentration‐time curve from time of dosing to infinity; AUC0–last, area under the plasma concentration‐time curve from time of dosing to the last observation; Cmax, maximum concentration; Tmax, time at which Cmax was observed; T1/2, apparent terminal half‐life; Vd, apparent volume of distribution of the drug; NC, not calculated.