FIG. 4.

Physiological changes. (A) Heart rate increased in humans, while no changes were observed in the mice after endotoxin administration. (B) Systolic blood pressure also increased slightly with no real change in the mice. In panels A and B, each value is the mean ± SEM (error bar) for 10 humans or 6 to 10 mice. (C) Body temperature increased in response to endotoxin in humans but no discernible pattern was seen in the mice. Data from two mice injected with saline are included to demonstrate that the changes in body temperature are not due to the endotoxin but to normal diurnal variations.