Fig. 3.

Effect of CGP52432 (intravenous) on the inhibition of bladder overactivity induced by tibial nerve stimulation (TNS) in male cats. A: repeated CMGs at different cumulative doses of CGP52432 were performed during acetic acid (AA) infusion with or without TNS. Black bars under the pressure trace indicate TNS duration. TNS: 5 Hz, 0.2 ms, T = 0.6 V. Infusion rate = 1 ml/min. B: normalized bladder capacity measured under different conditions (n = 5 cats). *Significantly (P < 0.05, Bonferroni comparisons) different from control at different dosages of CGP52432 (two-way ANOVA).