Table 3.

Univariable and multivariable linear regression analyses of sulfate clearance and clinical parameters in CHF

	Univariable Regression for Sulfate Clearance		Multivariable Regression for Sulfate Clearance
	Coefficient	P value	Coefficient	P value
Characteristics
Age	−0.545	<0.001‡
Male	−11.354	0.066
Current smoker	−0.975	0.710
BMI	0.141	0.703
Systolic blood pressure	0.035	0.713
Diastolic blood pressure	0.275	0.079
Heart rate	0.188	0.281
Heart failure history
Duration HF*	−0.793	0.649
Ischemic etiology	−2.542	0.475
NYHA class II/III	−14.112	0.005‡
LVEF	−0.040	0.838
Treatment
β-Blocker	10.838	0.243
MRA	−5.285	0.136
Diuretic	−9.389	0.003‡	−4.322	0.048‡
Laboratory measurements
NT-proBNP*	−6.689	<0.001‡
Serum albumin	1.877	0.004‡
Total serum protein	−0.651	0.117
Creatinine clearance	0.369	<0.001‡	0.331	<0.001‡
24-h Urinary albumin	0.046	0.098
24-h Urinary sodium	0.177	<0.001‡	0.077	0.023‡
HbA1C	2.422	0.356
Cholesterol	1.547	0.315
HDL	−7.268	0.088
LDL	1.930	0.271
Calcium	−21.940	0.257
PTH	−0.446	0.270
PRC*	−1.640	0.086
PRA*	−1.623	0.060
Aldosterone*	−4.281	0.032‡
1,25(OH)2D	0.046	0.207

CHF, chronic heart failure; BMI; body mass index; HF, heart failure; NYHA, New York Heart Association; LVEF, left ventricular ejection fraction; ACEi, angiotensin-converting enzyme inhibitor; ARB, angiotensin receptor blocker; MRA, mineralocorticoid-receptor antagonists; NT-proBNP; NH₂-terminal pro-B-type natriuretic peptide; HDL, high-density lipoprotein; LDL, low-density lipoprotein; PTH, parathyroid hormone; PRC, plasma renin concentration; PRA, plasma renin activity.

^*Skewed data, normalized by logarithmic transformation. ‡Significant P value.