Table 5.
By inflammatory cytokine and cytokine receptor gene array analysis, 16 genes were increased and 10 decreased in TG LV
WT | TG | P | |
---|---|---|---|
↑ in TG | |||
Abcf1 | 56.86 ± 2.89 | 84.56 ± 4.62 | <0.0001 |
Ccl11 | 0.67 ± 0.22 | 1.51 ± 0.25 | 0.0225 |
Ccl12 | 1.22 ± 0.43 | 4.95 ± 0.73 | 0.0003 |
Ccl4 | 0.32 ± 0.07 | 0.62 ± 0.07 | 0.0081 |
Ccr2 | 0.88 ± 0.19 | 1.78 ± 0.15 | 0.0020 |
Ccr3 | 0.35 ± 0.06 | 1.13 ± 0.13 | <0.0001 |
Ccr5 | 0.51 ± 0.20 | 2.72 ± 0.40 | <0.0001 |
Cxcr3 | 0.17 ± 0.04 | 0.38 ± 0.07 | 0.0091 |
Il10rb | 65.96 ± 7.93 | 124.36 ± 8.38 | <0.0001 |
Il13ra1 | 13.62 ± 1.13 | 18.93 ± 0.78 | 0.0021 |
Il15 | 22.15 ± 2.02 | 32.81 ± 1.82 | 0.0015 |
Il2rg | 8.06 ± 1.03 | 11.67 ± 0.80 | 0.0173 |
Itgb2 | 3.24 ± 0.28 | 5.05 ± 0.44 | 0.0024 |
Mif | 47.43 ± 6.08 | 145.7 ± 8.48 | <0.0001 |
Scye1 | 41.68 ± 4.04 | 76.53 ± 5.54 | <0.0001 |
Tnfrsf1a | 9.33 ± 0.62 | 14.72 ± 0.67 | <0.0001 |
↓ in TG | |||
C3 | 133.21 ± 11.06 | 90.97 ± 7.94 | 0.0093 |
Ccl19 | 24.52 ± 4.03 | 11.61 ± 0.87 | 0.0205 |
Ccl20 | 0.048 ± 0.005 | 0.030 ± 0.004 | 0.0193 |
Ccr9 | 1.44 ± 0.19 | 0.72 ± 0.13 | 0.0097 |
Il18 | 1.38 ± 0.21 | 0.63 ± 0.07 | 0.0044 |
Il1r1 | 13.59 ± 0.99 | 8.10 ± 0.43 | 0.0002 |
Il10 | 1.15 ± 0.27 | 0.37 ± 0.08 | 0.0155 |
Il13 | 0.21 ± 0.04 | 0.09 ± 0.02 | 0.0269 |
Il4 | 0.23 ± 0.05 | 0.08 ± 0.03 | 0.0352 |
Tgfb1 | 41.14 ± 3.56 | 27.54 ± 1.58 | 0.0051 |
Data are expressed as means ± SE. Gene expression was normalized to hypoxanthine-guanine phosphoribosyltransferase 1 and shown as 2−ΔCt × 100 units. All genes listed were P < 0.05 vs. WT (WT, n = 10; TG, n = 8). Underlines, proinflammatory genes.