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. 2016 Dec 16;312(3):H459–H468. doi: 10.1152/ajpheart.00498.2016

Fig. 6.

Fig. 6.

ANG-(1–7) infusion reduces LV fibrosis and restores LV function of HF-fed male MasR+/+ mice but has no effect on these parameters in HF-fed MasR−/− mice. ANG-(1–7) was infused to male mice via subcutaneous osmotic minipump at 1 mo of HF feeding for 28 days; LV function was assessed by echocardiography. A and B: EF (A) and FS (B) of HF-fed MasR+/+ and MasR−/− mice before and after ANG-(1–7) infusion. Data are means ± SE from 5 mice/genotype. *P < 0.05 compared with MasR−/− mice within time point. #P < 0.05 vs. 0 time point within genotype. C and D: interstitial collagen content is higher in HF-fed MasR−/− than MasR+/+ mice infused with ANG-(1–7). Representative images (×40) of Picro Sirius-stained sections (C) and quantification (D) of interstitial collagen content in the LV wall. Data are means ± SE from the average of 9 fields/mouse and 3 mice/group. *P < 0.05 compared with MasR+/+ mice.