Skip to main content
. 2016 Dec 23;312(3):H485–H500. doi: 10.1152/ajpheart.00035.2016

Fig. 8.

Fig. 8.

Inhibition of the phosphatidylinositol 3-kinase (PI3K) pathway inhibits the FSS upregulation of COX-2 protein and mRNA and release of PGI2 in ECs. A: COX-2 protein expression after BAECs were pretreated for 30 min with the PI3K inhibitor LY29 (30 μM) or with DMSO vehicle before exposure to fluid flow for 5 h (n = 4). B: FSS-induced COX-2 mRNA expression after treatment with the PI3K inhibitor LY29 (30 μM) and exposure to FSS for 5 h (n = 4). C: FSS-induced PGI2 production after treatment with the PI3K inhibitor LY29 (30 μM) and exposed to FSS for 5 h (n = 4). Values are means ± SE. *P < 0.05 vs. untreated static (S) controls. #P < 0.05 vs. untreated flow (F) controls.