Fig. 2.
SD and JCR rats were treated with 20-SOLA or 20-HEDGE (20-HETE antagonists) or 5,14,20-HEDGE (20-HETE mimetic) on days 2–9 of RI, or with microRNA-145 (miR-145) or anti-miR-145 on day 6 RI as indicated. A and C: coronary flow with or without adenosine and with or without nitroglycerine was measured in the CZ and NZ using microspheres during LAD occlusion and expressed as flow in the CZ in ml·min−1·g−1 over the time course of RI (left) and the flow ratio between the CZ and the NZ on day 9 RI (right). B: collateral arteries [smooth muscle-myosin heavy chain (SM-MHC)/PCNA-positive vessels >20 µM) and capillary (vessels <20 µM) densities were determined in cardiac (CZ) cross sections on day 9 RI; n = 8. *ξϕP < 0.05 as indicated.