Table 1.

Body weight, glucose and lipid profiles of the JCR:LA-cp rats

	Age, mo
	1		3		6		9		18
Male	+/+	cp/cp	+/+	cp/cp	+/+	cp/cp	+/+	cp/cp	+/+	cp/cp	References
Weight, g					343 ± 9	617 ± 24*			481 ± 23	1033 ± 38*
Fasting plasma glucose, mg/dl	105 ± 21	138 ± 43	116 ± 10	144 ± 18*	136 ± 12	137 ± 18	134 ± 24	125 ± 30			(8)
Plasma insulin concentrations, mU/l	5.2 ± 1.8	32 ± 16	23 ± 8	425 ± 85*	24 ± 1	350 ± 115*	52 ± 14	239 ± 80*			(8)
Plasma glucagon concentrations, ng/dl	186 ± 15	289 ± 90	103 ± 9	289 ± 13*	189 ± 22	296 ± 24*	207 ± 29	143 ± 27*			(8)
VLDL
VLDL cholesterol, mg/100 ml	1.1 ± 1.5	8.0 ± 2.6*	0.47 ± 1.4	7.7 ± 0.8*	0.49 ± 0.09	4.6 ± 0.9*	0.7 ± 0.3	3.1 ± 0.5*			(3, 4, 10)
Cholesterol esters, mg/100 ml	2.7 ± 3.9	16.6 ± 9.2	0.88 ± 0.20	11.3 ± 1.7*	0.71 ± 0.32	9.0 ± 1.2*	1.3 ± 0.7	6.5 ± 0.6*			(3, 4, 10)
Triacylglycerols, mg/100 ml	5.9 ± 5.2	145 ± 19*	6.4 ± 2.3	274 ± 27*	3.5 ± 1.6	169 ± 9.2*	12.3 ± 6.3	118 ± 13.8*			(3, 4, 10)
Phospholipids, mg/100 ml	4.2 ± 5.0	38.9 ± 10.3*	2.1 ± 0.47	52.8 ± 6.0*	0.88 ± 0.39	29.1 ± 2.5*	3.6 ± 1.6	18.5 ± 2.1*			(3, 4, 10)
HDL
HDL cholesterol, mg/100 ml	5.5 ± 1.1	6.2 ± 0.7	2.5 ± 0.6	4.3 ± 0.3*	2.9 ± 0.2	3.9 ± 0.6	2.6 ± 0.3	4.3 ± 0.4*			(3, 4, 10)
Cholesterol esters, mg/100 ml	63.0 ± 5.4	90.0 ± 8.9*	46.0 ± 9.5	96.9 ± 5.6*	57.8 ± 1.6	115.9 ± 7.3*	72.4 ± 6.0	96.3 ± 7.2*			(3, 4, 10)
Triacylglycerols, mg/100 ml	2.0 ± 1.8	0.3 ± 0.2	0.72 ± 0.96	1.1 ± 0.5	0.99 ± 0.52	2.7 ± 0.8*	0.88 ± 0.65	8.9 ± 0.7*			(3, 4, 10)
Phospholipids, mg/100 ml	47.2 ± 8.8	71.2 ± 5.9*	20.1 ± 5.6	69.4 ± 3.4*	19.2 ± 1.6	61.7 ± 4.1*	29.0 ± 6.0	56.4 ± 4.0*			(3, 4, 10)

Values are means ± SD, except weight (means ± SE).

^*P < 0.05 control vs. cp/cp male; n = 3–6.