Table 3. Summary risk estimates of the association between dairy foods and risk of stroke .
N b | No. of cases | Risk estimate (95% CI) | Heterogeneity test | References | |||
REM | I 2 (%) | P | P a | ||||
Total dairy | 19 | 29300 | 0.88(0.82-0.95) | 63.1 | 0.00 | ||
Outcome | 0.00 | ||||||
Incidence | 8 | 13979 | 0.96(0.88-1.04) | 49.7 | 0.05 | [13, 15, 20, 21, 36, 43, 47, 49] | |
Mortality | 11 | 15321 | 0.80(0.76-0.83) | 0.00 | 0.66 | [11, 16-18, 37, 41, 44, 45] | |
Location where the study was conducted | |||||||
Europe | 10 | 10985 | 0.96(0.89-1.04) | 29.8 | 0.17 | 1 | [11, 13, 20, 21, 36, 41, 45, 47, 49] |
Asia | 7 | 14109 | 0.79(0.75-0.82) | 0.00 | 0.73 | 0.00 | [16, 17, 37, 43, 44] |
Others | 2 | 4206 | 0.91(0.85-0.98) | 0.00 | 0.68 | 0.57 | [15, 18] |
Sex | 0.90 | ||||||
Male | 7 | 9007 | 0.92(0.79-1.07) | 68.5 | 0.00 | [13, 15, 17, 36, 37, 41, 45] | |
Female | 4 | 1021 | 0.78(0.66-0.91) | 0.00 | 0.67 | [17, 37, 41] | |
Quality | |||||||
High | 13 | 10343 | 0.89(0.85-0.94) | 0.00 | 0.44 | 1 | [11, 15, 17, 20, 21, 37, 41, 43, 44, 49] |
Moderate | 4 | 7731 | 1.01(0.84-1.21) | 63.9 | 0.04 | 0.05 | [13, 18, 36, 47] |
Low | 2 | 11226 | 0.79(0.75-0.83) | 0.00 | 0.90 | 0.26 | [16, 45] |
Adjusting for 4 or more covariates (smoking, alcohol, total energy intake, BMI, physical activity and ≥3 other dietary variables) (0.10) a | |||||||
Yes | 14 | 16368 | 0.91(0.85-0.98) | 49.1 | 0.02 | [13, 15, 17, 18, 20, 36, 37, 41, 47, 49] | |
No | 5 | 12932 | 0.79(0.75-0.83) | 0.00 | 0.98 | [11, 16, 43-45] | |
Fat content of dairy | 0.62 | ||||||
Low fat | 9 | 14689 | 0.94(0.90-0.98) | 0.00 | 0.61 | [13, 15, 18, 20, 41, 47, 49] | |
High fat | 9 | 14689 | 0.95(0.91-1) | 0.00 | 0.61 | [13, 15, 18, 20, 41, 47, 49] |
BMI: body mass index, REM: random effect model.
a P value for meta-regression, and location where the study was conducted (Europe as the reference) and Quality (high as the reference) and sex (male as the reference).
b N: number of results; 2 separate results (male and female) were available in 3 studies.17,37,41