TABLE 2.
ORs of myocardial infarction per 0.1% increase in total energy intake from LC n–3 PUFAs, EPA, DPA, and DHA and per 10-g increase in fish intake by rs11206510 (PCSK9) genotypes1
| Model 1 |
Model 2 |
|||
| Type of intake | OR (95% CI) | P-interaction | OR (95% CI) | P-interaction |
| LC n–3 PUFAs | 0.027 | 0.012 | ||
| Total population | 0.97 (0.91, 1.03) | 0.99 (0.92, 1.05) | ||
| *1T/*1T | 1.00 (0.94, 1.07) | 1.02 (0.95, 1.10) | ||
| *1C/*1T+*1C/*1C | 0.86 (0.74, 0.99) | 0.84 (0.72, 0.98) | ||
| EPA | 0.174 | 0.162 | ||
| Total population | 0.83 (0.69, 0.98) | 0.87 (0.72, 1.05) | ||
| *1T/*1T | 0.86 (0.71, 1.05) | 0.91 (0.73, 1.12) | ||
| *1C/*1T+*1C/*1C | 0.67 (0.44, 1.03) | 0.68 (0.43, 1.08) | ||
| DPA | 0.099 | 0.129 | ||
| Total population | 3.36 (2.09, 5.40) | 2.74 (1.65, 4.57) | ||
| *1T/*1T | 3.95 (2.33, 6.71) | 3.16 (1.79, 5.58) | ||
| *1C/*1T+*1C/*1C | 1.70 (0.57, 5.08) | 1.21 (0.37, 4.02) | ||
| DHA | 0.013 | 0.003 | ||
| Total population | 0.94 (0.85, 1.03) | 0.97 (0.87, 1.08) | ||
| *1T/*1T | 0.99 (0.89, 1.11) | 1.03 (0.92, 1.16) | ||
| *1C/*1T+*1C/*1C | 0.74 (0.59, 0.93) | 0.71 (0.55, 0.91) | ||
1
All intakes were energy adjusted. Model 1 (n = 3987) was adjusted for matching variables (age, sex, and area of residence). Model 2 (n = 3813) was adjusted as for model 1 and for waist-to-hip ratio, alcohol consumption, current smoking status, aspirin use, physical activity, family history of myocardial infarction, history of diabetes, history of hypertension, history of hypercholesterolemia, and genetic admixture. DPA, docosapentaenoic acid; LC, long chain; PCSK9, proprotein convertase subtilisin/kexin type 9.