TABLE 3.

ORs of myocardial infarction per minor allele of rs11206510 (PCSK9) by LC n–3 PUFAs, EPA, DPA, DHA, and fish intakes¹

		Model 1		Model 2
Type and tertile of intake	Mean ± SD2	OR (95% CI)	P-interaction	OR (95% CI)	P-interaction
LC n–3 PUFA, % of total energy intake			0.027		0.012
First	0.07 ± 0.02	1.05 (0.82, 1.35)		0.97 (0.74, 1.27)
Second	0.12 ± 0.01	0.71 (0.56, 0.91)		0.75 (0.58, 0.98)
Third	0.24 ± 0.12	0.71 (0.56, 0.91)		0.66 (0.51, 0.86)
EPA, % of total energy intake			0.174		0.162
First	0.02 ± 0.004	0.86 (0.67, 1.11)		0.82 (0.62, 1.07)
Second	0.03 ± 0.004	0.95 (0.75, 1.21)		0.97 (0.74, 1.25)
Third	0.07 ± 0.05	0.64 (0.50, 0.82)		0.60 (0.46, 0.78)
DPA, % of total energy intake			0.099		0.129
First	0.01 ± 0.004	0.93 (0.71, 1.20)		0.88 (0.67, 1.16)
Second	0.03 ± 0.003	0.86 (0.67, 1.11)		0.90 (0.68, 1.19)
Third	0.04 ± 0.01	0.69 (0.54, 0.86)		0.65 (0.51, 0.84)
DHA, % of total energy intake			0.013		0.003
First	0.03 ± 0.01	0.91 (0.71, 1.15)		0.87 (0.67, 1.13)
Second	0.06 ± 0.01	0.85 (0.66, 1.09)		0.87 (0.67, 1.13)
Third	0.14 ± 0.08	0.68 (0.53, 0.88)		0.61 (0.47, 0.81)

¹Model 1 (n = 3987) was adjusted for matching variables (age, sex, and area of residence). Model 2 (n = 3813) was adjusted as for model 1 and for waist-to-hip ratio, alcohol consumption, current smoking status, aspirin use, physical activity, family history of myocardial infarction, history of diabetes, history of hypertension, history of hypercholesterolemia, and genetic admixture. DPA, docosapentaenoic acid; LC, long chain; PCSK9, proprotein convertase subtilisin/kexin type 9.

²For continuous variables.