Figure 2.

Fusion design for translocation between specific partners. A fusion probe set contains two locus‐specific probes labelled with different colours targeting the genes known to fuse in certain tumours or diseases. The fusion probes identify chromosomal loci far from each other either on the same chromosome or on different chromosomes. The wild type configuration shows two separated signals resulting from physically separated chromosome loci (A). When fusion occurs, the two probes move to a closely approximated position (fusion signal, B). This provides direct evidence of a gene fusion with definitive fusion partners identified.