Table 3. Effects of sildenafil on N-terminal pro-B-type natriuretic peptide (NT-proBNP), electrocardiographic parameters and blood pressures in dogs with naturally occurring, asymptomatic myxomatous mitral valve degeneration.
| Parameters | Time (Day) | Sildenafil | Control | P value |
|---|---|---|---|---|
| NTproBNP (pg/ml) | 0 | 92.8 ± 9.0 | 56.1 ± 7.9 | 0.007 |
| NTproBNP (% change from BL) | 30 | 14.3 ± 9.8 | 45.2 ± 22.8 | 0.200 |
| 90 | −7.4 ± 10.9 | 63.4 ± 26.9 | 0.017 | |
| 180 | −2.2 ± 12.4 | 73.3 ± 26.6 | 0.013 | |
| RR (ms) | 0 | 614.0 ± 26.4 | 590.9 ± 52.4 | 0.683 |
| RR (% change from BL) | 30 | 5.08 ± 5.75 | 7.10 ± 10.50 | 0.879 |
| 90 | 6.19 ± 3.66 | 10.76 ± 10.09 | 0.693 | |
| 180 | −0.37 ± 4.08 | 13.17 ± 11.45 | 0.307 | |
| PQ (ms) | 0 | 92.3 ± 4.7 | 98.1 ± 6.3 | 0.466 |
| PQ (% change from BL) | 30 | 3.02 ± 1.90 | −1.43 ± 3.09 | 0.280 |
| 90 | −0.62 ± 2.42 | −1.02 ± 4.05 | 0.940 | |
| 180 | 0.75 ± 2.06 | 2.98 ± 3.31 | 0.610 | |
| QRS (ms) | 0 | 46.7 ± 2.3 | 47.5 ± 2.3 | 0.799 |
| QRS (% change from BL) | 30 | 14.35 ± 3.82 | 11.92 ± 6.41 | 0.771 |
| 90 | 12.34 ± 3.07 | 4.94 ± 2.33 | 0.122 | |
| 180 | 19.24 ± 3.34 | 8.04 ± 5.72 | 0.140 | |
| QT (ms) | 0 | 193.4 ± 4.0 | 195.6 ± 3.9 | 0.701 |
| QT (% change from BL) | 30 | 0.60 ± 2.65 | −1.51 ± 1.78 | 0.588 |
| 90 | -0.06 ± 1.85 | −1.42 ± 1.59 | 0.640 | |
| 180 | −2.00 ± 1.84 | 2.03 ± 1.04 | 0.134 | |
| QTc (V) (ms) | 0 | 193.4 ± 4.0 | 195.6 ± 3.9 | 0.701 |
| QTc (V) (% change from BL) | 30 | 0.60 ± 2.64 | −1.50 ± 1.78 | 0.588 |
| 90 | -0.06 ± 1.85 | −1.42 ± 1.59 | 0.640 | |
| 180 | −1.58 ± 1.82 | 2.03 ± 1.04 | 0.171 | |
| SBP (mmHg) | 0 | 122.77 ± 4.57 | 127.73 ± 5.26 | 0.428 |
| SBP (% change from BL) | 30 | 16.26 ± 4.33 | 1.72 ± 6.80 | 0.175 |
| 90 | 9.11 ± 4.57 | 2.11 ± 4.77 | 0.500 | |
| 180 | 5.96 ± 4.05 | 8.54 ± 6.32 | 0.905 | |
| MBP (mmHg) | 0 | 98.58 ± 4.47 | 101.58 ± 4.53 | 0.606 |
| MBP (% change from BL) | 30 | 13.27 ± 4.26 | 3.66 ± 8.31 | 0.384 |
| 90 | 4.38 ± 4.70 | 1.52 ± 4.71 | 0.874 | |
| 180 | 3.62 ± 4.43 | 8.93 ± 7.37 | 0.765 | |
| DBP (mmHg) | 0 | 81.55 ± 3.93 | 82.55 ± 4.28 | 0.445 |
| DBP (% change from BL) | 30 | 10.87 ± 4.76 | 0.94 ± 7.61 | 0.143 |
| 90 | 0.10 ± 5.97 | −1.34 ± 4.41 | 0.707 | |
| 180 | 2.00 ± 5.66 | 10.85 ± 8.60 | 0.520 |
Values at day 0 are presented as actual number, whereas values at days 30, 90 and 180 are presented as percent change from baseline. Data are presented as mean ± standard error mean (SEM). The differences between groups at the same timepoint were compared using Student t-test, and values of P<0.05 were considered significance. BL: Baseline, SBP: Systolic blood pressure, MBP: Mean blood pressure, DBP: Diastolic blood pressure.