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. 2017 Apr 24;7:46698. doi: 10.1038/srep46698

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Copyright © 2017, The Author(s)

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(a) In BMVECs under OGD conditions, both endogenous and exogenous 15-HETE (1μmol/L) increased PI3K/Akt expression. (n = 4, *p < 0.05, **p < 0.01). Values are represented as the mean ± S.E.M. (b) Pretreatment with LY-294002 blocked the effects of 15-HETE on cell migration. (c) The increased PCNA expression after 15-HETE under OGD was blocked by the PI3K/Akt inhibitor. (d) Pretreatment of LY-294002 blocked the exogenous 15-HETE-induced BrdU incorporation. (n = 4, *p < 0.05, **p < 0.01). Values are represented as the mean ± S.E.M. (e) Flow cytometry for cell-cycle analysis indicated that 15-HETE stimulated BMVEC progression into G₂/M + S phase, and this effect was blocked by LY-294002. (f) LY-294002 also blocked the increase in cyclin A or (g) cyclin D, induced by 15-HETE. (n = 4, *p < 0.05, **p < 0.01). Values are represented as the mean ± S.E.M.