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. 2005 Jan 1;19(1):138–151. doi: 10.1101/gad.1246005

Figure 1.

Figure 1.

Conditional deletion of numb in the developing sensory ganglia. (A–E) The recombination pattern of Wnt1Cre in trunk neural crest and developing sensory ganglia was examined by crossing Wnt1Cre transgenic mice with ROSA26 mice. The regions where recombination occurred showed intense lacZ staining. (A,B) Wnt1Cre recombination pattern at E9.5 was revealed in whole-mount staining (A) and tissue sections at the trunk level (indicated by arrows in A). (B,C) lacZ+ cell in the dorsal spinal cord (arrowhead in B) and in scattered cells in the migratory paths of trunk neural crest (arrow). A few lacZ+ cells are identified around dorsal aorta (DA) at the presumptive site for future sympathetic ganglion (arrow in B). (C) Whole-mount lacZ staining in E10.5 embryo showed intense lacZ+ cells in the coalesced DRG. (D) LacZ+ cells were also present in the sympathetic ganglia (SG) adjacent to the DA. (E) At E15.5, essentially every cell within the dorsal root ganglion is positive for lacZ. (F–I) No detectable amount of Numb protein was identified in the sensory ganglia of Wnt1Cre/+;fnb/fnb at E11.5 (H) and E15.5 (I). Bars: B,D,E, 50 μm; F–I, 20 μm.