Figure 6.

Uncoupling of endothelial nitric oxide synthase (eNOS) contributes to the exacerbated myocardial ischemia/reperfusion injury (MI/R).

Note: (A) Experimental protocol. (B, C) Myocardial area-at-risk (AAR) as a percentage (%) of total left ventricle (LV) (B) and infarct size (INF) as a percentage of AAR(C). Numbers inside bars indicates sample size. Values are expressed as the mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001. SED: Sedentary; VE: voluntary exercise; BH₄: tetrahydrobiopterin intervention; WT; Wild-type mice.