Figure 1.

Amplification of carbon monoxide (CO) production by rat brain microsomes by menadione (MD).

Note: The open circles show the CO production when reaction mixture contained 50 μM methemalbumin (MHA), 1 mg microsomal protein and MD as indicated on the abscissa in 100 mM phosphate buffer (pH 7.4). The solid triangles show the effect of 25 μM QC-321 (heme oxygenase inhibitor) in addition to MHA, microsomes and MD. Bars represent SD, where bars are not shown the SD is smaller than the symbol; n = 4. Significantly differences, *P < 0.05. The inset shows the structure of MD.