Table 1. Summary of the EGFR mutations discussed in the manuscript alongside their aa-RFC predicted phenotype and, when available, the experimentally reported effect to gefitinib treatment found in literature.

Mutation	NMR	Predicted class	Gefitinib phenotype	Reported in TCGA
L792P	0.88	SRES	Proposed resistant (Unconfirmed)	No
M793L	0.85	SRES		No
D855N	1.0	SRES		No
G719S	0.83	RES	Increase Sensitivity to gefitinib and erlotinib	LUAD
G719A	0.63	RES	Contradictory	LUAD
G719R	0.68	RES		No
G719C	0.65	RES		No
G719D	0.64	RES		No
G719V	0.86	SRES		No
T790M	0.34	ISEN	Increase Sensitivity gefitinib and erlotinib	LUAD
R776H	0.24	ISEN	Increase Sensitivity gefitinib and erlotinib	LUAD
C775Y	0.66	SRES	Unknown	No
H835Y	0.84	SRES		No
G796V	0.85	SRES		No