Figure 1. Modulation of GABA response by curcumol in cultured hippocampal neurons.

(a) Chemical structures of curcumol and other GABA_AR ligands or modulators used in the present study. (b) Representative traces showing the currents evoked by different concentrations of GABA (black) alone, or curcumol (50 μM) plus various concentrations of GABA (red) as indicated. (c) Concentration–response curves of GABA for currents evoked in the absence (black squares) or presence (red circles) of 50 μM curcumol. Current amplitudes were normalized to the maximal response. These values were derived from previously published data³³, regraphed here in a different way to assess the effect of curcumol on GABA concentration-response curve. The EC₅₀ and Hill coefficient values were 2.4 ± 0.4 μM, 2.0 ± 0.6 without curcumol and 1.7 ± 0.2 μM, 1.9 ± 0.3 with curcumol, respectively. n = 6 each group.