Figure 2. Interplay between diazepam (DZP) and curcumol on GABA-induced currents in cultured hippocampal neurons.

(a) Representative traces of GABA (1 μM)-induced currents in the absence or presence of DZP (1 μM) or curcumol (50 μM). (b) Pooled data from (a). (c–e) Histograms showing relative I_DZP, I_GABA, I_DZP+GABA, I_Curcumol, I_{Curcumol+GABA}, and I_{DZP+Curcumol+GABA}. I_Curcumol, curcumol-activated current; I_{Curcumol+GABA}, current activated by curcumol and GABA; I_DZP, diazepam-activated current; I_DZP+GABA, current activated by DZP and GABA; I_{DZP+Curcumol+GABA}, current activated by DZP, curcumol and GABA; I_GABA, GABA-activated current. Data represent peak current amplitude normalized to that induced by GABA (1 μM) alone (dashed line). n = 6 each group. ^**P < 0.01, ^***P < 0.001, compared with the current induced by GABA alone (dashed line); ^#P < 0.05, ^##P < 0.01, ^###P < 0.001, compared as indicated, paired Student’s t-test.