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. 2017 Apr 24;7:46654. doi: 10.1038/srep46654

Figure 5. Effects of point mutations in β2 subunit of GABAAR on the modulation of α1-β2-γ2 GABAAR subtype by curcumol, menthol, or DZP.

Figure 5

(a, c, e) Representative current traces induced by GABA (1 μM) in the absence or presence of curcumol (50 μM), menthol (300 μM), or DZP (1 μM) in HEK-293T cells that expressed α1, β2, β2-M286W, or β2-Y444W, and γ2 GABAAR subunits. (b, d, f) Pooled data from (a), (c) and (e), respectively. Data represent peak current amplitude normalized to that induced by GABA (1 μM) alone (dashed line). n = 3–8 each group. N.S., not significant, *P < 0.05, **P < 0.01, compared with the current induced by GABA alone (dashed line), paired Student’s t-test.