Figure 7. Effects of point mutations in γ2 subunit of GABA_AR on the modulation of α1-β2-γ2 or α5-β2-γ2 GABA_AR by curcumol, menthol, or DZP.

(a, c) Representative current traces induced by GABA (1 μM) in the absence or presence of curcumol (50 μM), menthol (300 μM), or DZP (1 μM) in HEK-293T cells that expressed α1 or α5, β2, and γ2-F77Y GABA_AR subunits. (b, d) Pooled data from (a) and (c), respectively. Data represent peak current amplitude normalized to that induced by GABA (1 μM) alone (dashed line). n = 4–8 each group. N.S., not significant, ^**P < 0.01, ^***P < 0.001, compared with the current induced by GABA alone (dashed line), paired Student’s t-test.