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. 2017 Apr 24;7:46654. doi: 10.1038/srep46654

Figure 8. A hypothetical scheme for the modulation of GABA(A) receptors by curcumol, menthol, or DZP through different mechanisms.

Figure 8

(a) For the α1-β2-γ2 GABAAR, while curcumol and menthol but not DZP act the receptor through the sites of Met-286 (M286) and Tyr-444 (Y444) in the β2 subunit, DZP but not curcumol nor menthol acts the receptor through Phe-77 (F77) in the γ2 subunit. (b) For the α5-β2-γ2 GABAAR, while curcumol acts the receptor through the sites of M286 and Y444, menthol acts the receptor through the site of M286 but not that of M444 in the β2 subunit, DZP but not curcumol nor menthol acts the receptor through Phe-77 (F77) in the γ2 subunit. Please see the text for more details.