Table S4.

Subgroup analysis

Region	Receptor binding VT				Student’s t test P value
	n = 6 SD52 Low diff	n = 8 SD52 High diff	n = 6 REC14 Low diff	n = 8 REC14 High diff	Unpaired	Paired	Paired
					SD52 low diff vs. SD52 high diff	SD52 low diff vs. REC14 low diff	SD52 high diff vs.REC14 high diff
Anterior cingulate cortex	0.73	0.83	0.71	0.67	0.119	0.849	0.010
Insula	0.79	0.91	0.78	0.74	0.090	0.846	0.011
Amygdala	0.69	0.87	0.70	0.67	0.007	0.863	0.007
Hippocampus	0.71	0.82	0.70	0.66	0.040	0.890	0.005
Frontal cotex	0.84	0.95	0.83	0.77	0.076	0.936	0.003
Orbitofrontal cortex	0.76	0.86	0.72	0.72	0.152	0.606	0.039
Occipital cortex	0.86	0.97	0.84	0.79	0.131	0.782	0.012
Temporal cortex	0.79	0.92	0.78	0.75	0.072	0.972	0.023
Thalamus	0.81	0.93	0.78	0.74	0.105	0.704	0.007
Striatum	0.80	0.92	0.79	0.70	0.058	0.911	0.0003

Regional A₁AR distribution volumes [V_T; (mL/mL)] in two groups after 8-h control sleep, 52 h of sleep deprivation, and 14-h recovery sleep and subgroups with minor and predominant changes. Values are given as mean; statistical comparisons that exceed the multiple-comparison–adjusted threshold (FDR, Benjamini and Hochberg method) are in boldface. diff, difference.