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. 2017 Apr 3;114(16):4195–4200. doi: 10.1073/pnas.1618934114

Fig. 1.

Fig. 1.

Recent O2 experience regulates CO2-evoked arousal. (A) N2 animals and npr-1 animals acclimated to 7% O2 persistently increase their speed when CO2 rises to 3%; npr-1 animals acclimated to 21% O2 do not. n = 247–302 animals. ****P < 0.0001; ns, not significant; Wilcoxon signed-rank test. Animals were assayed on food at 7% O2. In this and subsequent figures, animals were acclimated to 21% O2 unless noted otherwise; solid lines indicate the mean and shaded areas, the SEM. Black bars here and throughout indicate intervals used for statistical comparisons; boxplots show the median and the 25th–75th percentiles; whiskers represent 10th–90th percentiles. (B) Selectively expressing NPR-1 215V in RMG, (C) disrupting gcy-35, or (D) RNAi knockdown of EGL-21 in RMG prevent npr-1 animals acclimated to 21% O2 from suppressing CO2-evoked arousal. n = 104–235.