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. 2017 Mar 20;114(16):E3334–E3343. doi: 10.1073/pnas.1616467114

Fig. 5.

Fig. 5.

Global and neuron but not granulosa cell loss of AR signaling protects against the development of obesity in the PCOS mouse model. (A) Body weight, confirming DHT-induced increased body weight in WT mice and showing no significant increase in body weight in DHT-induced PCOS ARKO or NeurARKO female mice. Data are the mean ± SEM; n = 5 to 9 mice per genotype/treatment group. (B) Parametrial fat deposit weight, showing no significant increase in adiposity in DHT-induced PCOS ARKO or NeurARKO female mice. Data are the mean ± SEM; n = 5 to 9 per genotype/treatment group. (C) Representative dual-energy X-ray absorptiometry images, showing no development of obesity in DHT-induced PCOS ARKO female mice. G, genotype; ns, no significant difference; T, DHT treatment; *, significant difference. (*P < 0.05, two-way ANOVA.)