Table S1.

Baseline phenotypic characteristics of the different ARKO mouse models, compared with their strain-matched WT controls

ARKO mouse model	ARKO	NeurARKO	GCARKO
Estrous cycles	Irregular estrous cycles	Normal estrous cycles	Normal estrous cycles
Serum steroids and hormones	No change in DHT, T, DHEA, P4, or 3α- and 3β-diol at diestrus	No change in DHT, T, DHEA, P4, or 3α- and 3β-diol at diestrus	No change in DHT, T, DHEA, P4, or 3α- and 3β-diol at diestrus
Ovarian morphology	Ovaries normal in appearance	Ovaries normal in appearance	Ovaries normal in appearance
	↓Ovary weight	No change in ovary weight	No change in ovary weight
Follicle populations	No change in growing follicle populations	No change in growing follicle populations	No change in growing follicle populations
Follicle health	↓Large antral follicle health	↓Large antral follicle health	No change in follicle health
Ovulation	↓CL	No change in CL populations	No change in CL populations
Body weight	No change	No change	No change
Adipocyte hypertrophy	↑Adipocyte size	No change	No change
Dyslipidemia	No change in cholesterol or triglycerides	No change in cholesterol or triglycerides	↑Cholesterol, no change in triglycerides
Hepatic steatosis	Not present	Not present	Not present
Impaired fasting glucose	No change	No change	↓Fasting glucose levels