Table S2.

Correlation matrix of mental health and physical health summary scores calculated using different methodologies

Reference population	Roche reference	Roche reference, sample Z scores	Ugandan reference
Mental health
Roche reference	1
Roche reference, sample Z scores	0.9988***	1
Ugandan reference	0.9106***	0.9177***	1
Ugandan reference, sample Z scores	0.9115***	0.9171***	0.9985***
Physical health
Roche reference	1
Roche reference, sample Z scores	0.9987***	1
Ugandan reference	0.9421***	0.9364***	1
Ugandan reference, sample Z scores	0.9612***	0.9606***	0.9882***

The Roche reference population refers to a population of HIV+ patients in a high-income setting, and it is the population described in the MOS-HIV manual and used most widely (44). The Ugandan reference population is a more recently validated sample of Ugandan HIV+ patients who entered the study with low CD4 counts (42). Summary scores are calculated using factor weightings from the reference population and Z scores. We calculated and compared these summary metrics using weights from each reference population (Roche reference, Ugandan reference) and Z scores from our study population (sample Z scores) and the validated reference populations. Our results are highly correlated using all methods, and we elect to use the Roche reference population in all subsequent analyses for its wide reference and the relative similarity of our average scores to the averages for this reference group.

^***P < 0.001.