. 2017 Apr 3;114(16):4189–4194. doi: 10.1073/pnas.1617042114

Table 1.

Nine genetic loci with signals of natural selection

Chromosome	SNP	bp	A1	A2	Frequency of A1		P value	F_ST	Nearest gene
Chromosome	SNP	bp	A1	A2	Tibetan	EAS	P value	F_ST	Nearest gene
1	rs1801133	11,856,378	A	G	0.238	0.333	6.3E-09	0.021	MTHFR
1	rs71673426	112,159,304	C	T	0.102	0.013	1.5E-08	0.100	RAP1A
1	rs78720557	198,096,548	A	T	0.498	0.201	4.7E-08	0.191	NEK7
1	rs78561501	231,448,497	A	G	0.599	0.135	6.1E-15	0.414	EGLN1
2	rs116611511	46,600,030	G	A	0.447	0.003	3.6E-19	0.570	EPAS1
4	rs2584462	100,324,464	G	A	0.211	0.549	3.9E-09	0.203	ADH7
5	rs4498258	44,325,322	T	A	0.586	0.287	1.7E-08	0.171	FGF10
6	rs9275281	32,662,920	G	A	0.095	0.365	1.1E-10	0.162	HLA-DQB1
12	rs139129572	123,178,478	GA	G	0.316	0.449	5.8E-09	0.036	HCAR2

P value indicates the P value from the MLMA-LOCO analysis. F_ST is the F_ST value between Tibetans and EASs. Nearest gene indicates the nearest annotated gene to the top differentiated SNP at each locus except EGLN1, which is known to be associated with high-altitude adaptation; rs139129572 is an insertion SNP with two alleles: GA and G. A1, allele 1; A2, allele 2.