Table 1.
Chromosome | SNP | bp | A1 | A2 | Frequency of A1 | P value | FST | Nearest gene | |
Tibetan | EAS | ||||||||
1 | rs1801133 | 11,856,378 | A | G | 0.238 | 0.333 | 6.3E-09 | 0.021 | MTHFR |
1 | rs71673426 | 112,159,304 | C | T | 0.102 | 0.013 | 1.5E-08 | 0.100 | RAP1A |
1 | rs78720557 | 198,096,548 | A | T | 0.498 | 0.201 | 4.7E-08 | 0.191 | NEK7 |
1 | rs78561501 | 231,448,497 | A | G | 0.599 | 0.135 | 6.1E-15 | 0.414 | EGLN1 |
2 | rs116611511 | 46,600,030 | G | A | 0.447 | 0.003 | 3.6E-19 | 0.570 | EPAS1 |
4 | rs2584462 | 100,324,464 | G | A | 0.211 | 0.549 | 3.9E-09 | 0.203 | ADH7 |
5 | rs4498258 | 44,325,322 | T | A | 0.586 | 0.287 | 1.7E-08 | 0.171 | FGF10 |
6 | rs9275281 | 32,662,920 | G | A | 0.095 | 0.365 | 1.1E-10 | 0.162 | HLA-DQB1 |
12 | rs139129572 | 123,178,478 | GA | G | 0.316 | 0.449 | 5.8E-09 | 0.036 | HCAR2 |
P value indicates the P value from the MLMA-LOCO analysis. FST is the FST value between Tibetans and EASs. Nearest gene indicates the nearest annotated gene to the top differentiated SNP at each locus except EGLN1, which is known to be associated with high-altitude adaptation; rs139129572 is an insertion SNP with two alleles: GA and G. A1, allele 1; A2, allele 2.