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. Author manuscript; available in PMC: 2018 Apr 21.
Published in final edited form as: J Mol Biol. 2017 Mar 11;429(8):1143–1154. doi: 10.1016/j.jmb.2017.03.007

Figure 1.

Figure 1

Components of gene expression noise. Gene expression noise can be decomposed into intrinsic and extrinsic contributions in single cells using two distinguishable fluorescent reporter genes, CFP and YFP, expressed from identical promoters and integrated at distinct genomic loci. Extrinsic noise produces proportional CFP and YFP expression in each cell. Intrinsic noise produces independent CFP and YFP expression in each cell. Adapted from [21].