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. Author manuscript; available in PMC: 2018 May 1.
Published in final edited form as: Psychoneuroendocrinology. 2017 Feb 11;79:59–66. doi: 10.1016/j.psyneuen.2017.02.006

Figure 5.

Figure 5

Tumor-induced inflammation is attenuated by minocycline treatment. Minocycline treatment significantly reduced IL1β within the liver with a trend toward a reduction in TNFα (A). Further, minocycline resulted in a significant reduction in the expression of CD11b, a marker of activated monocytes, within the liver (likely kupffer cells in this model; Vichaya et al., 2016) (A). Within the brain, minocycline significantly reduced the expression of IL1β mRNA expression (B). Finally, circulating levels of IL6 were significantly reduced following minocycline treatment. n=9 mice/group. * p<0.05