Table 1.

Questionnaire of musculoskeletal pain following discontinuation of tyrosine kinase inhibitors in patients with chronic myeloid leukemia.

1. Select the discontinued tyrosine kinase inhibitor below:

□ Glivec □ Tasigna □ Sprycel

2. While you were taking the drug selected in Question 1, did you experience any muscle or joint pain? If yes, please select the degree of such pain.

Specific site: (          )

1. Pain not limiting exercise or lifestyle,

2. Pain not causing problems in daily lifestyle but impairing exercise, activities, etc.,

3. Pain limiting daily lifestyle

3. After discontinuation of the drug selected in Question 1, did you experience any muscle or joint pain? If yes, please select the degree of such pain.

Specific site: (             )

Time between discontinuation and the appearance of symptoms: (          )

1. Pain not limiting exercise or lifestyle,

2. Pain not causing problems in daily lifestyle but impairing exercise, activities, etc.,

3. Pain limiting daily lifestyle

4. If, in Question 3, you answered that you experienced physical changes after discontinuation of the drug, for how long did those symptoms persist? Furthermore, was any medication used to treat the symptoms?

Symptom/s that appeared (          )

Duration (          )

Treatment (          )

5. If administration of a tyrosine kinase inhibitor was restarted after discontinuation, did your symptoms change (improve/worsen) after restarting the drug?

□ No change

□ Improvement

□ Exacerbation/new appearance

(          )