Fig. 5.

Estimated age and degree of divergence from subfamily consensus sequence of AluS TPRT insertion candidates. a For each of the AluS TPRT insertion candidates (n = 7) percent divergence from the respective AluS subfamily consensus sequence is shown along with estimated ages for the elements based on CpG and non-CpG substitution rates. b Boxplot of percent divergence from the respective AluS subfamily consensus sequence of all AluS elements annotated in the reference genome (n = 686,955) and the TPRT insertion candidates (n = 7). c The TPRT insertion candidates (n = 7) are significantly less diverged from their respective AluS subfamily consensus sequence than are all the AluS elements annotated in the reference genome (n = 686,955) from their respective subfamily consensus sequence (p = 0.0038, permutation test). The distribution of the mean percent divergence of 1 × 10⁶ random samples of n = 7 drawn from the total 686,955 AluS elements annotated in the reference genome is shown. The mean percent divergence of the seven TPRT insertion candidates is shown as a vertical red line