Fig. 6.

Conservation of functionally significant Alu sequence features in the seven classical TPRT insertion candidates. a WebLogo diagram [47] of the RNA polymerase III promoter A and B boxes, with the published consensus sequences depicted below in grayscale [33]. CpG sites are indicated by an orange arrow. b WebLogo diagram [47] of the SRP9/14 binding sites. Previously reported most highly conserved sites within the SRP9/14 binding sites of elements capable of retrotransposition are underlined by a purple bar [16]. CpG sites are indicated by an orange arrow. c WebLogo diagram [47] of two AC dinucleotides in the Alu sequence reported to play a critical role in maintaining the closed loop conformation of Alu RNA that is important for interaction with SRP9/14 and efficient retrotransposition [34]