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. 2017 Feb 24;158(5):822–832. doi: 10.1097/j.pain.0000000000000832

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Copyright © 2017 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the International Association for the Study of Pain

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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Figure 1. — Inhibiting protein kinase G-1 (PKG-1) reduces complete Freund's adjuvant (CFA)-induced thermal hyperalgesia. Paw withdrawal latency (PWL) to heat stimuli was assessed (pre-CFA) and then 100 ul CFA was injected into the plantar surface of the right hind paw. One day later (post-CFA day 1), when the rats exhibited thermal hyperalgesia, Rp-8-pCPT-cGMPS (RPG) (100, 125, and 250 nmol, n = 6, 6, and 10, respectively) or the vehicle control (saline, n = 10) was administered intrathecally as indicated by arrow. Paw withdrawal latency was measured again the following day (post-CFA day 2). (A) Data (mean ± SEM) indicated that injection of 250 nmol RPG resulted in a significant improvement in mean PWL compared to the vehicle control (P = 0.001). (B) Mean PWL in the contralateral hind paw.