Figure 7.

The activation of axonal PKG by capsaicin. Capsaicin (0.1 μM) was locally injected under the perineurium of the sciatic nerve. An equal volume of vehicle was administered into the contralateral nerve. Thirty minutes later, the 1 cm nerve segment containing the injection site from each nerve was harvested, homogenized, and assayed for PKG-1α activity. PKG activity appeared in the capsaicin-treated nerve segment (dark grey bar), but not in the vehicle treated nerve (open bar), (P < 0.05; N = 4). Data represent mean ± SEM.