Figure 8.
Circadian rhythm of arterial plasma leptin (ng/mL) concentrations in rats that underwent isoflurane anesthesia (blue) compared with brief CO2 anesthesia (amber). Black bars represent the dark phase; *, significant (P < 0.05) difference between groups. Values are double plotted to show rhythmicity. The total numbers of samples at time points 0400, 0800, 1200, 1600, 2000, and 2400 were 6, 6, 5, 5, 6, and 6 for the isoflurane group and 6, 9, 7, 11, 6, and 8 for the CO2 group, respectively. For reference, the gray line represents the mean values reported in Sprague–Dawley rats.45