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Titanium implantation is likely associated with a proinflammatory state. (A through C) Creatinine and (D through F) cholesterol were compared (A and D) between implanted and nonimplanted macaques, (B and E) between animals that had 2 or more implants, 1 implant, or no implant, and (C and F) between animals that were implanted for 0 to 3 y, 4 to 6 y, or 7 y or more. *, Statistically significant relationship (P < 0.05).
