Table 4.
Inhibition of CYP1A1-, 1A2, and 1B1-dependent EROD activities and CYP2A6- and 2A13-dependent coumarin 7-hydroxylation activities by organoselenium compounds
| (Chemical) (P450) | BSC | o-XSC | m-XSC | p-XSC |
|---|---|---|---|---|
|
| ||||
| IC50 (μM) for inhibition of EROD activity | ||||
| CYP1A1 | 0.45 ± 0.038 | 0.11 ± 0.021 | 0.10 ± 0.013 | 0.26 ± 0.031 |
| CYP1A2 | 1.3 ± 0.22 | 0.39 ± 0.042 | 0.20 ± 0.021 | 0.63 ± 0.059 |
| CYP1B1 | 0.27 ± 0.031 | 0.14 ± 0.027 | 0.13 ± 0.011 | 0.16 ± 0.009 |
|
| ||||
| (Chemical) (P450) | BSC | o-XSC | m-XSC | p-XSC |
|
| ||||
| IC50 (μM) for inhibition of coumarin 7-hydroxylation activity | ||||
|
| ||||
| CYP2A6 | 4.3 ± 0.36 | 2.7 ± 0.34 | 2.4 ± 0.19 | 6.2 ± 0.55 |
| CYP2A13 | 1.2 ± 0.19 | 1.2 ± 0.13 | 0.22 ± 0.031 | 1.4 ± 0.21 |
IC50 values were obtained by measuring EROD activities for CYP1A1, 1A2, and 1B1 and coumarin 7-hydroxylation activities for CYP2A6 and 2A13. Data for IC50 values represent means ± SE. Data are taken from from Shimada et al. (25) with modification.