Figure 4.

Influence of Aβ incubation time on the formation of Aβ oligomer and the current.

Notes: (A) Dependence of the current on the incubation time for the preparation of Aβ oligomer. The final concentrations of AgNPs, PrP_95–110 and Aβ sample were kept at 1.2 nM, 100 nM and 1 μM, respectively. (B) AFM images of the mica substrate after incubation with Aβ samples pre-incubated for 24 and 48 h. I_pa, oxidation current.

Abbreviations: Aβ, beta-amyloid; AgNP, silver nanoparticle; PrP, prion protein; AFM, atomic force microscopy.