Table 2.

Subgroup analysis of follow-up time and symptom severity at baseline

Trials	Follow-up time				Symptom severity at baseline
	Middle point		End point		Mild–moderate		Severe symptoms symptoms
	Outcomes	P-value	Outcomes	P-value	Outcomes	P-value	Outcomes	P-value
Muresanu et al18	ARAT scale	<0.0001	ARAT scale 12 different outcome scales on global status	<0.0001 <0.0001	N/A	N/A	ARAT scale 12 different outcome scales on global status	<0.0001 <0.0001
Chang et al17	FMA scale Fractional anisotropy Axial diffusivity Radial diffusivity rsfMRI	>0.05 >0.05 >0.05 >0.05 >0.05	FMA scale Fractional anisotropy Axial diffusivity Radial diffusivity rsfMRI	>0.05 >0.05 <0.01 <0.01 >0.05	FMA scale	>0.05	FMA scale	<0.05
Amiri-Nikpour et al16	NIHSS Velocity of right MCA Velocity of left MCA Velocity of BA Right MCA PI Left MCA PI BA PI	0.092 0.033 0.768 0.610 0.010 0.286 0.384	NIHSS Velocity of right MCA Velocity of left MCA Velocity of basilar BA Right MCA PI Left MCA PI BA PI	0.001 0.065 0.638 0.657 0.014 0.277 0.828	N/A	N/A	N/A	N/A
Lang et al15	mRS NIHSS BI	0.366 0.038 0.841	mRS NIHSS BI GOS scale	0.984 0.490 0.673 0.882	N/A	N/A	N/A	N/A
Heiss et al14	–	–	mRS NIHSS BI SF-12	>0.05 >0.05 >0.05 >0.05	mRS NIHSS BI	>0.05 >0.05 >0.05	mRS NIHSS	0.09 0.04
Ladurner et al13	CNS section A1 MMSE SST	<0.05 <0.05 <0.05	CNS CNS section A1 BI GCS CGI MMSE SST	>0.05 >0.05 >0.05 >0.05 >0.05 >0.05 <0.05	N/A	N/A	N/A	N/A

Abbreviations: ARAT, Action Research Arm Test; BA, basilar artery; BI, Barthel index; CGI, clinical global impression; CNS, Canadian Neurological Scale; FMA, Fugl–Meyer Assessment; GCS, Glasgow Coma Scale; GOS, Glasgow Outcome Scale; MCA, middle cerebral artery; MMSE, Mini-Mental State Examination; mRS, modified Rankin Scale; N/A, not applicable; NIHSS, National Institutes of Health Stroke Scale; PI, pulsatility index; rsfMRI, resting-state functional magnetic resonance imaging; SF-12, short form 12 items; SST, Syndrome Short Test.