Table 2.
PPIUDCS
| Author (year) | Study design and IUD | Population | Comparison | Event rates
|
Comments | ||
|---|---|---|---|---|---|---|---|
| Expulsion | Medical removal | Pregnancy | |||||
| Bhutta et ala,7 (2011) | MLCu 375 insertion at CS vs 6 W and no IUD | PPIUDCS 50 IIUDCS 50 Control 50 |
Post-placental vs 6W vs no IUD | Same in all groups No numbers given |
Same in all groups No numbers given |
0 | 6 M follow-up. No difference in puerperal bleeding in all groups |
| Elsedeeka,10 (2012) | Nova T 380 vs Mirena vs control at CS | Nova T 380 63 Mirena 60 Control 63 |
Nova T vs Mirena on puerperal bleeding | Nova T 7.9% Mirena 0% |
0 0 |
0 0 |
Nonrandom. 6 W follow-up. Mirena group bled significantly less |
| López-Farfan et al9 (2012) | Mirena vs TCu380A at CS. RCT | Mirena 198 TCu380A 198 |
Mirena vs TCu380A | Mirena 4.5% TCu380A 4.5% |
2% 3.5% |
0 0 |
12 M percentage rates |
| Gueye et al19 (2013) | Open evaluation of TCu380A at CS. Uncontrolled |
PPIUDCS 56 | 0 | 2.2% | 2.3% | 0 | 6 M percentage follow-up rates |
| Singal et al21 (2014) | Open evaluation of TCu380A at CS | PPIUDCS 300 | 0 | 5.23% | 7% | 0.6% | 12 M percentage rates |
| Tjahjannto et al20 (2014) | Open evaluation of TCu380A sutured to fundus at CS “hang-up” technique | PPIUDCS 108 | 0 | 0 | 0.95% | 0.9% | Pearl index and percentage rates at 12 M |
| Whitaker et al17 (2014) | Mirena at CS vs at 4–8 W post-CS. RCT | PPIUDCS 20 IIUDCS 22 |
Mirena at CS vs later insertion at post-partum visit | At CS 20% At 4–8 W 0% |
Not stated | 0 0 |
12 M follow-up. Percentage rates |
| Braniff et al13 (2015) | Mirena at CS vs 6 W post-CS. RCT | PPIUDCS 23 IIUDCS 19 |
Mirena at CS vs later insertion at post-partum visit | At CS 0% At 6 W 0% |
Not stated | 0 0 |
6 M follow-up. Percentage rates. High satisfaction in both groups |
| Lester et al12 (2015) | TCu380A at CS vs 6 W post-CS. RCT | PPIUDCS 34 IIUDCS 18 |
TCu380A at CS vs later insertion at post-partum visit | At CS 3% At 6 W 5% |
At CS 3% At 6 W 5% |
0 0 |
6 M follow-up. Percentage rates |
| Levi et al15 (2015) | Comparison of Mirena and TCu380A at CS vs 6 W+ post-CS. RCT as to timing of insertion | Mirena PPIUDCS 40 TCu380A PPIUDCS 15 Mirena IIUDCS 30 TCu380A IIUDCS 4 |
Mirena or TCu380A at CS vs later insertion at post-partum visit | At CS (combined results) 8% At 6 W (combined results) 2% | At CS (combined results) 15% At 6 W (combined results) 4% | 0 0 |
6 M follow-up. Percentage rates. Participants selected type of IUD |
| Elsedeek11 (2015) | Mirena vs Nova T 380 at CS. Open study | Mirena 80 Nova T 63 |
Mirena vs Nova T at patient request | Mirena 0% Nova T 6.3% |
Mirena 3.8% Nova T 7.9% |
Nova T 6.3% Mirena 0% |
60 M follow-up. Percentage rates, misalignment at 6 W more common with Mirena |
| Ragab et al14 (2015) | Nova T 380 vs TCu380A vs MLCu 375 at CS. RCT | Nova T 380 40 TCu380A 40 MLCu 375 40 |
Three-way comparison of different copper IUDs inserted at CS | Nova T 13% TCu380 15% MLCu 5.6% |
Not stated | Nova T 3% TCu380 3% MLCu 0% |
12 M follow-up. Percentage rates. Expulsion rate of MLCu 375 was significantly lower than the other two Strings lengthened with vicaryl |
Notes: Results from December 2012 to June 2015 search, unless otherwise stated.
a
Included from earlier search because of widened inclusion criteria. Mirena (Bayer AG, Levekusen, Germany); Nova T 380 (Bayer AG); MLCu 375 (Multiload Copper 375; Multilan SA, Fribourg, Switzerland); TCu380A, Teva Pharmaceutical Industries Ltd., Petach Tikva, Israel).
Abbreviations: PPIUDCS, post-placental IUD at CS; IIUDCS, interval insertion of IUD after CS; CS, cesarean section; IUD, intrauterine contraceptive device; RCT, randomized controlled trial; vs, versus; W, weeks; M, months.