Table S4.
Parameters included in probabilistic sensitivity analysis
| Parameter | Distribution |
|---|---|
| Utility at each TWSTRS score (based on mapping) | Multivariate normal (Cholesky) |
| Mean baseline TWSTRS distribution, nonresponders and responders at 0, 4, 8, 12 weeks | Gamma |
| Transition probability: response to secondary nonresponse | Beta |
| Duration of treatment cycle: abobotulinumtoxinA | Gamma |
| Treatment discontinuation rate per year | Gamma |
| AbobotulinumtoxinA_first injection dosage | Gamma |
| AbobotulinumtoxinA_reinjection dosage: nonresponder | Gamma |
| AbobotulinumtoxinA_reinjection dosage: responder | Gamma |
| Setting where drug is administered (distribution) | |
| Neurologist visit | Beta |
| Physiotherapist visit | Beta |
| Nurse visit | Beta |
| Disease management | |
| Neurologist visit (excluding BoNT-A injection) per year | Gamma |
| GP visit per year | Gamma |
| Hospitalization rate per year: BoNT-A | Beta |
| Hospitalization rate per year: BSC | Beta |
| Length of stay for hospitalization: BoNT-A | Gamma |
| Length of stay for hospitalization: BSC | Gamma |
Abbreviations: BSC, best supportive care; BoNT-A, botulinum neurotoxin type A; GP, general practitioner; TWSTRS, Toronto Western Spasmodic Torticollis Rating Scale.