Table 1.

Estimated 95% CI of natural cognitive decline without treatment according to the modified Mendiondo’s model

Age, years	Baseline MMSE	Half year		1 year
		Lower CI	Upper CI	Lower CI	Upper CI
<72	3	1.37	1.69	−0.26	0.38
	4	2.08	2.55	0.17	1.10
	5	2.73	3.41	0.46	1.81
	6	3.29	4.27	0.58	2.54
	7	3.76	5.15	0.52	3.29
	8	4.14	6.05	0.28	4.10
	9	4.45	6.99	−0.10	4.98
	10	4.77	7.98	−0.46	5.96
	11	5.23	9.01	−0.54	7.02
	12	5.97	10.09	−0.05	8.18
	13	7.09	11.20	1.18	9.40
	14	8.54	12.33	3.08	10.66
	15	10.18	13.47	5.37	11.94
	16	11.88	14.61	7.76	13.22
	17	13.53	15.75	10.07	14.50
	18	15.10	16.88	12.20	15.75
	19	16.57	17.99	14.15	16.98
	20	17.96	19.09	15.92	18.19
	21	19.27	20.19	17.54	19.37
	22	20.52	21.27	19.04	20.54
	23	21.73	22.34	20.46	21.68
	24	22.90	23.40	21.79	22.81
≥72	3	1.83	2.06	0.67	1.12
	4	2.63	2.96	1.25	1.92
	5	3.37	3.86	1.74	2.72
	6	4.06	4.76	2.12	3.52
	7	4.68	5.67	2.36	4.34
	8	5.23	6.60	2.46	5.20
	9	5.74	7.56	2.48	6.12
	10	6.25	8.55	2.50	7.10
	11	6.86	9.57	2.73	8.15
	12	7.68	10.63	3.36	9.26
	13	8.76	11.71	4.53	10.42
	14	10.09	12.80	6.17	11.60
	15	11.55	13.90	8.10	12.81
	16	13.05	15.00	10.10	14.01
	17	14.52	16.10	12.03	15.21
	18	15.92	17.19	13.84	16.39
	19	17.26	18.28	15.52	17.55
	20	18.54	19.35	17.07	18.70
	21	19.76	20.42	18.52	19.83
	22	20.94	21.48	19.88	20.95
	23	22.09	22.53	21.18	22.05
	24	23.21	23.57	22.42	23.14

Abbreviations: CI, confidence interval; MMSE, mini mental state examination.