Figure 2.

Brain bacterial loads in mice that had signs of neurologic involvement and succumbed to infection with MSHR543 (bim_Bm) and MSHR305 (bim_Bp) Burkholderia pseudomallei isolates. Bacterial loads in brains of C57BL/6 mice (MSHR543, n = 4; MSHR305, n = 5) that had become moribund and required euthanasia within the 21-day experimental period after intranasal infection with MSHR543 (1.4 × 10⁴ CFU; white bars) and MSHR305 (1.1 × 10⁴ CFU; black bars). N indicates mice that displayed symptoms of neurologic involvement. Data are expressed as log₁₀ CFU. Mice exposed to MSHR543 (bim_Bm) had signs of neurologic involvement and became moribund within 7 days of exposure.